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Research - Progenex Cocoon


When it comes to maintaining peak athletic performance and consistently making speed and strength gains, recovery is key. That is why PROGENEX is proud to present the perfect companion to our post-workout recovery protein supplement – PROGENEX Cocoon.


What Do Nursery Rhymes and Night time Have to Do with Recovery?

PROGENEX Cocoon is all about night time rest and recovery. Lets begin our discussion  with a little bedtime nursery rhyme. “Little Miss Muffet sat on a tuffet; eating her curds and whey?”  . . what in the world are curds and whey? If you answered cheese curds, you are correct! 

Miss Muffet was actually consuming two very superior sources of protein. Curds come from casein, and casein is the main protein found in cow’s milk. In fact, casein protein makes up approximately 80% of the protein found in cow’s milk, while the remaining 20% consists of whey protein. As complete proteins, both casein and whey serve as stellar sources of muscle fuel. Both possess unique amino acid profiles that when combined with their differing rates of digestion, make them remarkably suited to enhance muscle growth, repair, and recovery.

Whey is a fast-digesting or rapidly absorbed protein, making it the ideal pre- and post-workout protein supplement of choice (that is why PROGENEX Recovery protein supplement consists of 100% whey protein hydrolysate). The rapid and ready absorption is just what your starving muscles need for optimum recovery after a killer workout. Casein, on the other hand, congeals in the stomach, resulting in slower metabolization. This longer digestion time provides your skeletal muscles with a sustained release of amino acids–making micellar casein the perfect protein choice for PROGENEX Cocoon protein supplement: the ultimate in night time rest and recovery.


How does this clotting of casein in the gut actually occur? It’s quite similar to the process of making cheese. You see, casein curdles in acidic environments. When manufacturers make cheese, they simply add a substance with a low pH to the milk causing the casein to curdle while the whey goes by the “whey” side. This is how you get your curds and whey. So what Miss Muffet was actually eating was something very similar to cottage cheese. Although today, the milky liquid found in cottage cheese is not usually whey. Most people wouldn’t find cottage cheese and whey very appetizing.

Back to the clotting of casein. The acidic nature of your stomach is what actually causes the casein to clot during digestion. This coagulation slows its digestion, enabling the casein to serve as a time-released protein supplement that peaks hours after consumption, supplying your muscles with a slow and steady drip of amino acids. Again, the best time to ingest casein protein is right before bed so that your muscles are fed a slow and steady supply of protein while you sleep.


And that is why the central ingredient in our night-time rest and recovery protein supplement is micellar casein.

Studies on micellar casein have demonstrated its remarkable ability to:

  • Stimulate protein synthesis (Tipton, 2004)

  • Increase lean muscle mass and strength (Demling, 2000),  (Willoughby, 2007)

  • Prevent muscle wasting (Boirie Y, 1997)

  • Speed recovery (Cermak, 2012)

  •  Improve immunity (Gregory, 2008)

  • Enhance satiety (Abou-Samra, 2011), and

  • Reduce blood pressure (Cadee, 2007)



Micellar casein, however, is only one of the ingredients that make PROGENEX Cocoon protein supplement the ultimate in night time rest and recovery. PROGENEX Cocoon protein supplement also features Metamorphagen™—our proprietary tryptophan peptide that reduces sleep interruptions while fostering a deep, sound, restorative sleep so that you wake up feeling strong, rested and fully recovered.*

Furthermore, you won’t have to worry about drowsiness because the precise amount of Metamorphagen™ was specially formulated to wrap you in a cocoon of recovery at night so that come morning you are ready to hit it hard, maintaining peak performance levels all day long!



Most people associate tryptophan with turkey. Science has proved the positive relation between the two (tryptophan and sleep).

Over 30 years ago, Dr. Hartman discovered L-tryptophan’s ability to reduce sleep latency (the amount of time it takes an individual to fall asleep), while simultaneously promoting a deep, less-interrupted sleep (Hartman, 1982). Studies demonstrating the power of tryptophan are not limited to just adults. Recently, scientists substantiated tryptophan’s capability to improve infant sleep (Aparicio, 2007). For years, tryptophan has been added to infant formula and for good reason. It works! Both parents and babies sleep more soundly because of it.

But that is not all, the tryptophan peptide has also been shown to improve and enhance sleep for individuals struggling with sleep disorders such as insomnia (Schneider-Helmet, 1986) (Hudson,2005), sleep apnea (Schmidt, 1983) and sleep phase delay (Cooke, 2010).





As an essential amino acid, L-tryptophan enters the bloodstream through the walls of the intestinal tract. L-tryptophan serves as a precursor for the production of serotonin. You see, when L-tryptophan crosses the brain-blood barrier, the brain converts it into 5-hyrdoxytryptophan, or 5-HTP, and then into serotonin. Serotonin plays an important role in regulating sleep, mood and appetite. When it comes to sleep, low serotonin levels negatively impact sleep/wake cycles (Miyamoto, 2012), as well as result in numerous sleeping disorders (Soulairac, 1977), (Wyatt, 1971). Disrupted sleep can ultimately lead to even greater problems such as chronic fatigue syndrome and/or depression. Whereas, sound and sufficient sleep not only results in happier, non-sleep deprived people, it can help you achieve your best body composition ever, as well as improve immunological function.



As you may know, getting adequate sleep is essential when it comes to maximizing anabolic hormone production—both testosterone and human growth hormone (HGH). Both of these hormones are regulated by our circadian rhythms—with HGH being produced in waves during deep, REM sleep (fully 70% of HGH production occurs during sleep) (Van Cauter, 1998), and testosterone production growing during sleep and peaking around dawn.

While men obviously produce more testosterone than women—and it’s contribution to protein synthesis and anabolic drive are well known—HGH is both anabolic (promotes protein synthesis) and lipolytic (promotes fat burning) (Bidlingmaier, 2010). Thus, HGH is a key hormone to staying lean. And sufficient sleep is a must for optimal HGH production. 

Improved Immune Function

Allow me to remind you of how important sleep is when it comes to immune system support. In case you are unfamiliar with the research, I highly recommend visiting one of the most recent studies conducted on sleep and improved immune function by Besedovsky and his colleagues, wherein a substantial review of the science of sleep and enhanced immunological defences is thoroughly detailed and discussed. You’ll probably find more than you cared to know about the sleep dependent activity of T cells and regulatory T cells, but the numerous studies—fully cited in the reference section—are quite handy and helpful (Besedovsky, 2012). Basically, the better you sleep, the better you will feel, and the better equipped your body will be to fight off illness and maintain optimal immune system support.

Improved Mood

Back to serotonin. In addition to regulating sleep, serotonin also plays an important role in governing mood and behaviour. Since L-tryptophan serves as a precursor to serotonin production, Metamorphagen™ can also help elevate your mood. Studies on depression and its treatment have consistently demonstrated L-tryptophan’s ability to increase serotonin production, thereby improving overall mood while ameliorating depressive symptoms (Thomson, 1982), (Levitan, 2000).

Appetite Control

Serotonin is also responsible for appetite regulation. Serotonin inhibits neuropeptide Y, resulting in the suppression of hunger and food intake (Halford & Blundell, 2000). Conversely, a low brain 5-HT level (translate as serotonin level) is associated with enhanced appetite (Leibowitz, 1989) and impaired impulse control (in rats) (Bizot, 1999). Since tryptophan levels directly impact the production of serotonin, PROGENEX Cocoon’s Metamorphagen™ can help you feel satiated as you soundly sleep.

Peptide Power

Now that you understand the many benefits of L-tryptophan, allow me to explain what makes Metamorphagen™ such a powerful, proprietary addition to our night time formula. PROGENEX Metamorphagen™ contains L-tryptophan in peptide form. Proteins in peptide form have superior absorption rates, protein efficiency ratios, and have been shown to enhance and speed recovery much more effectively than proteins in amino acid form (Boza, 2000), (Poullain, 1989). Consequently, L-tryptophan in peptide form is more potent and powerful than L-tryptophan in amino acid form (Markus, 2008). And that, coupled with our precise dosing, is what makes Metamorphagen™–our special proprietary L-tryptophan peptide—the finest L-tryptophan ingredient.



Night time recovery is crucial for daytime performance. Featuring the powerful ingredients, micellar casein and Metamorphagen™, PROGENEX Cocoon protein supplement provides just what your body needs to train hard, sleep well, and recover strong! 

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